专利名称：TARGETED OSMOTIC LYSIS OF CANCER
CELLS
发明人：PAUL, Dennis, J.,GOULD, Harry, J.申请号：EP12814986.1申请日：20120719公开号：EP2734214A1公开日：20140528
摘要：A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gatedsodium channels (VGSCs) has been developed that uses a combined therapy of a drugthat blocks sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase) that is thenfollowed by an activation of VGSCs, for example, by electrical or pharmacologicalstimulation. Activation of VGSCs conducts sodium into the cancer cells in much greateramounts than non-cancer cells. Water follows this sodium gradient into the cancer cells,causing swelling and lysis. Because non-cancerous cells do not over-express VGSCs, lesssodium and less water will enter the cells, and the non-cancerous cells will not lyse. Thismethod is applicable to all cells that over-express VGSCs, including, but not limited to,highly invasive breast cancer, prostate cancer, small cell lung cancer, non-small cell lungcarcinoma, lymphoma, mesothelioma, neuroblastoma, and cervical cancer.
申请人：BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY ANDAGRICULTURAL AND MECHANICAL COLLEGE
地址：115 System Building, 3810 W. Lakeshore Drive Baton Rouge, LA 70808 US
国籍：US
代理机构：WP Thompson
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