NANOSTRUCTURES AND APPLICATIONS THEREOF

专利名称：NANOSTRUCTURES AND APPLICATIONS

THEREOF

发明人：AXELSSON, Oskar,BÄCKSTRÖM,

Sania,PETORAL JR, Rodrigo

申请号：EP15712905.7申请日：20150327公开号：EP3122383A1公开日：20170201

摘要：Disclosed herein are globular nanostructures having a hydrodynamic diameter(D h ) of 8-100 nm comprising a central part and a peripheral part, wherein said centralpart has a calculated diameter (D c ) of 6-90 nm and said peripheral part has an estimatedthickness (Tp) so that D h =D c +2T p , wherein said central part comprises: (i) a

crosslinked polymeric framework comprising monomer residues wherein at least 30 % bynumber of the monomer residues have crosslinked thereby forming the crosslinkedpolymeric framework and/or (ii) a branched polymeric framework comprising monomerresidues wherein the number of branch points is at least 30 % of the number of monomerresidues, wherein said central part comprises chelating groups of which at least 4 allowchelation of at least one multiply charged cation, wherein said chelating groups areindependently selected from the group consisting of-COOR 1 , -P=O(OR 1 )(OR 2 ), and -S(=O) 2 OR 1 , wherein R 1 and R 2 are independently selected from the group consistingof a negative charge, H, and lower alkyls, and wherein said peripheral part comprises asynthetic polymer material covalently attached to the central part, wherein the syntheticpolymer material is hydrophilic and bioinert, and electrically neutral or zwitterionic. Also

disclosed are compositions comprising such nanoparticles, and optionally also aradionuclide, use of such compositions, kits containing such compositions and methodsfor obtaining such compositions.

申请人：Spago Nanomedical AB

地址：Medicon Village Scheelevägen 2 223 81 Lund SE

国籍：SE

代理机构：Ström & Gulliksson AB

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